➀ Researchers developed lipid nanoparticles (LNPs) to deliver mRNA encoding the KRAS G12D neoantigen and cGAMP to reprogram the liver's immune environment and generate an antitumor response against metastatic pancreatic cancer.

➁ The LNPs successfully activated the type I interferon pathway, leading to the generation of CD8+ cytotoxic T cells capable of recognizing and attacking metastatic cancer cells.

➂ The study suggests that combining KRAS mRNA with a STING agonist strengthens the immune response against PDAC and offers a more effective approach than traditional immunotherapies.

➀ Ed reflects on the sources of €1trn and his strategy to secure a share of it;

➁ Ed discusses the possibility of the US raising €800 billion for 'ReArm Europe' and €200 billion for 'InvestAI';

➂ Ed's assignment to the EU as 'Digital Envoy' and his plan to spend on meals and indulgences to identify influential figures in the spending of the funds.

➀ A new type of miniaturized pumps and valves using ultra-thin silicon films is presented at the Hannover Messe, developed by researchers at Saarland University. These pumps and valves operate without air pressure, motors, and lubricants, and can be operated in clean rooms. The team demonstrates a prototype of a new vacuum pump that can draw a vacuum up to 300 millibars.

➁ The technology is cost-effective, lightweight, and energy-efficient compared to current methods, with a 400 times lower energy consumption compared to conventional air-driven valves.

➂ The researchers have developed a novel actuator and pump technology that can be used in various applications, including robotic grippers, speakers, smart textiles, and haptic feedback.

➀ A team from Saarland University's Faculty of Engineering and Medicine is developing smart implants at the university and university hospital to monitor and promote healing in body bone fractures.

➁ The robotic implants can stiffen and soften through shape-memory technology, allowing for permanent monitoring of fracture healing.

➂ The research team is miniaturizing the technology for use in market screws as part of an EU project.

➀ The Nvidia GeForce RTX 5070 Founders Edition offers a 20% performance increase over its predecessor and a $549 MSRP.

➁ Concerns over retail availability and pricing, with potential for significantly higher prices in the short term.

➂ AMD's RX 9070 launch scheduled for the same day, posing competition and availability challenges.

➀ Lois Rossmann, a renowned RepairTuber, expresses disappointment with Brother's shift towards becoming an 'anti-consumer printer company';

➁ Brother's recent firmware updates have disabled third-party toner and prevented color registration functionality on color devices;

➂ Older firmware versions are being removed from support portals, making it difficult for users to roll back updates.

➀ NVIDIA CEO Jensen Huang introduced new tools at CES 2025 aimed at democratizing AI access for everyone, not just researchers or large enterprises.

➁ These tools include Project DIGITS, NEMO, and Blackwell GPUs, which are designed to be portable, scalable, and easy to use, reducing the barriers to AI adoption.

➂ The introduction of these tools aims to simplify workflows, lower the barrier to entry, and empower individuals and small teams with AI capabilities.

➀ Sen, a UK startup, has launched a 4K live stream from the International Space Station (ISS), providing real-time views of Earth and space.

➁ The 4K camera system, named 'SpaceTV-1', includes three different camera views: a wide-angle panoramic view of Earth's horizon, a downward view covering an area of 240 km x 180 km, and a forward-facing view of the space station's docking port.

➂ The live stream is available on Sen's website, some mobile apps, and YouTube. Sen plans to launch more video cameras into space to enhance its livestreaming capabilities in 2026 and beyond.

➀ DeepSeek, a Chinese AI software developer, claims it can train leading AI programs at a fraction of the cost compared to top US developers.

➁ DeepSeek recently launched R1, a program trained on 2000 Nvidia GPUs, which outperforms models from OpenAI, Anthropic, and xAI's Grok.

➂ The company also offers V3, which is free but requires payment for integration with its infrastructure. V3 excels in inference speed and competes with the most advanced closed-source models globally.

➀ The Fraunhofer Institute for Microstructure of Materials and Systems IMWS is working on a project called FA2IR with partners to develop solutions for using digital tools for fault analysis.

➁ The project aims to automate AI-assisted analysis to reduce subjectivity, shorten development times, and improve product quality.

➂ The initiative seeks to create comprehensive and fully integrated environments for processing and managing digital data, algorithms, methods, and models for machine learning that are globally applicable and can be dynamically expanded.

➀ The article lists the top ten technologies that are most likely to transform the world, as recommended by Technology Magazine.

➁ These technologies include GenAI, AI & Machine Learning, Quantum Computing, 5G, VR/AR, IoT, Blockchain & decentralized technologies, Green tech, BioTech & personalized medicines, and Robots & Automation.

➂ It highlights the potential impact of these technologies across various sectors including healthcare, industry, and sustainability.

➀ Neil Druckmann discussed the evolving role of storytelling in video games with screenwriter Alex Garland, reflecting on the challenges and inspirations around narratives in games.

➁ Games like BioShock and The Last of Us demonstrated the full capability of narrative in gaming, challenging the industry's skepticism.

➂ Druckmann shared his early inspirations for narrative-driven games, including Monkey Island 2 and Half-Life 2.

➀ Reputable leaker Billbil-Kun reports that Death Stranding 2 pre-orders are expected to start in March, with a release date likely announced at SXSW 2025.

➁ The game will have a Standard Edition at $69.99 and a Collector's Edition at $229.

➂ The leak also confirms that Death Stranding 2 will launch with a physical Standard Edition, priced at $69.99 USD / 69.99 EUR, along with a Collector's Edition planned for North America and Europe, retailing at $229 USD.

➀ Dr. Prady Gupta is the Founder and Chief Scientist at Infinita Lab and Infinita Materials, focusing on materials testing and specialized chemicals for high-tech industries.

➁ Infinita Lab offers a network of over 2,000 accredited labs for comprehensive materials testing services.

➂ Infinita Materials specializes in custom inorganic chemicals for sectors like semiconductors and batteries.

➀ This paper discusses the post-silicon validation of the IBM POWER9 processor, highlighting its significance in the context of increasing multi-core processor adoption by hyperscalers.

➁ IBM's Threadmill, a tool for processor verification, has been enhanced since the POWER7, including optimized template allocation and debugging strategies for multi-core write drops.

➂ The validation methodology for POWER9 has significantly improved bug detection rates compared to POWER8, with new techniques like AI prioritization and hardware irritators to induce bugs.