➀ The rise of 2.5D and 3D multi-die designs driven by high-performance computing and AI; ➁ Challenges in architecture and early prototyping, including thermal management and mechanical reliability; ➂ The importance of early verification to prevent costly delays and suboptimal performance; ➃ The role of AI in optimizing design processes and outcomes; ➄ The significance of sign-off tools for ensuring reliability and longevity of multi-die designs.