➀ This study explores the use of Sele-targeted siRNA liposome nanoparticles to inhibit pathological scar formation by disrupting communication between monocytes and endothelial cells. ➁ The research, conducted using a mouse model, investigates the mechanisms of scar development and evaluates the effectiveness of the targeted therapy. ➂ Results indicate reduced scar formation with lower collagen deposition and fewer inflammatory cells in treated mice, suggesting the potential of this approach for scar management therapies.