➀ The research introduces polymer-based nano-PROTACs to improve the delivery and efficacy of treatments for colorectal cancer; ➁ The study demonstrates the enhanced permeation and retention effect of PSRNs in tumor tissues, leading to increased therapeutic potential; ➂ In vivo studies show improved survival rates with PSRNs combined with immune checkpoint inhibitors.

1. The article reviews advancements in using nanomaterials to induce ferroptosis in cancer cells, focusing on molecular dynamics and innovative therapy strategies. 2. It highlights studies where nanomaterials like gold nanoparticles and lipid/polymeric nanoparticles were used to target cancer cells effectively. 3. The development of multifunctional nanoplatforms integrating therapeutic and diagnostic functionalities is discussed, showing potential for personalized cancer therapy.