1. Researchers developed a self-assembled nanocomposite, DOX/TPOR4@CB[7]4, for enhanced synergistic photodynamic therapy and chemotherapy in neuroblastoma treatment; 2. The nanocomposite showed significant anti-tumor effects both in vitro and in vivo, with efficient ROS generation and minimal toxicity; 3. This novel approach holds promise for improving therapeutic outcomes in neuroblastoma.