➀ The study developed a novel cancer vaccine combining Nano-11, a plant-derived nanoparticle, with ADU-S100, a STING agonist, to enhance antitumor immunity. ➁ The combination significantly boosted immune responses, including increased antibody levels and activated CD8+ T cells, leading to reduced tumor growth in mice. ➂ The vaccine showed no significant adverse effects, suggesting potential for future clinical applications in cancer treatment.