<p>➀ This study presents a green synthesis method for silver nanoparticles using pomegranate peel extract, highlighting its potential as a sustainable alternative to traditional chemical synthesis.</p><p>➁ The researchers optimized the synthesis process using a Box–Behnken design, resulting in silver nanoparticles with controlled size and good dispersion.</p><p>➂ The synthesized nanoparticles exhibited enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, indicating their potential for biomedical applications.</p>