➀ University of Bath physicists lead a team that has made a significant breakthrough in nanotechnology, enabling control over single-molecule chemical reactions. This has profound implications for fundamental scientific understanding and could transform the development of new medications. ➁ The research, published in Nature Communications, uses a scanning tunnelling microscope to control the probability of reaction outcomes by selectively manipulating charge states and resonances. ➂ The findings could lead to new frontiers in molecular manufacturing, with potential applications in medicine, clean energy, and beyond.