➀ Researchers at the University of Osnabrück have developed a microscopy method that allows simultaneous imaging and analysis of molecular interactions and their immediate nanoenvironment in living cells with high temporal and spatial resolution. ➁ The new fluorescence microscope opens up new possibilities for tracking molecular processes in real-time and correlating them with the overarching dynamics of cellular structures. ➂ The unique new system combines two high-resolution microscopy techniques, enabling direct visualization of individual protein complex formations in the cell membrane and deeper insights into the signal activation of immune receptors.